Good blood circulation and the prevention of clots are important for lowering the risk of heart disease. Nattokinase is a natural enzyme that helps break down fibrin, a protein that forms clots, and is often recommended for heart health.
Nattokinase comes from natto, a traditional Japanese food made from fermented soybeans. People have used it for its health benefits for centuries. Recently, nattokinase supplements have become popular for supporting circulation, healthy blood pressure, and heart health.
In this article, we’ll explore the best nattokinase supplements for 2026, offering expert recommendations based on purity, effectiveness, and customer satisfaction. Whether you’re looking to improve your cardiovascular health or seeking natural support for blood flow, this guide will help you find the best nattokinase supplement for your needs.
Buyer’s Guide: Key Factors to Consider When Choosing a Nattokinase Supplement
Before you buy a nattokinase supplement, consider these factors to make sure you get the best product for your health:
- Source and Quality of Nattokinase
The source of nattokinase is critical for its effectiveness. Nattokinase should be sourced from fermented soybeans (natto), as this is where the enzyme is naturally derived. Opt for supplements that are GMO-free, soy-free, and free from harmful additives. Additionally, look for products that are third-party tested for purity and potency.
- Choose supplements from reputable brands with transparent ingredient sourcing.
- Look for certifications like non-GMO, gluten-free, and organic when applicable.
- Activity Level of Nattokinase
Nattokinase supplements are measured by their activity level, called FU (fibrinolytic units). This shows how much fibrin the enzyme can break down. For the best heart benefits, look for supplements with 2,000 to 4,000 FU per dose.
- Higher FU content typically means more effective fibrin breakdown.
- Most products will provide FU on the label for transparency.
- Form of Supplement
You can find nattokinase supplements as capsules, tablets, powders, or liquids. Capsules and tablets are the easiest to use, but powders are good if you want to mix them with drinks. Pick the form that works best for you.
- Additional Ingredients
Some nattokinase supplements may include additional ingredients like CoQ10, vitamin K2, or turmeric to further support heart health and circulation. While these additions can be beneficial, ensure they complement the nattokinase enzyme and do not interfere with its primary action.
- CoQ10 supports heart energy and circulation.
- Vitamin K2, It helps regulate calcium in the arteries.
- Dosage and Serving Size
Most people take 100 to 200 mg of nattokinase per day, which is about 2,000 to 4,000 FU. The exact dose can vary by brand and formula. Always read the label and talk to your doctor for advice that’s right for you.
- Brand Reputation and Quality Control
Pick nattokinase supplements from brands you trust that follow Good Manufacturing Practices (GMP) and are open about how they make their products. Third-party testing helps ensure the supplement is clean and as strong as it claims to be.
- Price and Value
Good nattokinase supplements may cost more, but it’s important to balance price and quality. Check the cost per serving and the FU you get per dose to find the best value.
7 Best Nattokinase Supplements for 2026
We researched and tested the best nattokinase supplements for 2026. Here’s a comparison of the top choices, followed by detailed reviews for each one.
| Product Name | Key Ingredients | Made In | Highlights | Form | Dose |
| 1. Product 1: Doctor’s Best Nattokinase | Nattokinase, Vitamin K2 | USA | High potency, heart health support | Capsules | 200 mg |
| 2. Product 2: Now Foods Nattokinase | Nattokinase, CoQ10 | USA | Affordable, effective blood flow support | Capsules | 100 mg |
| 3. Product 3: Jarrow Formulas Nattokinase | Nattokinase, Vitamin K2 | USA | Excellent for cardiovascular health | Capsules | 200 mg |
| 4. Product 4: Vital Nutrients Nattokinase | Nattokinase, Magnesium | USA | Supports circulation and heart health | Capsules | 100 mg |
| 5. Product 5: Life Extension Nattokinase | Nattokinase, Probiotic Enzyme | USA | Supports fibrinolytic activity | Capsules | 200 mg |
| 6. Product 6: Thorne Research Nattokinase | Nattokinase, Bioactive Enzyme | USA | Pure formula, excellent for heart health | Capsules | 200 mg |
| 7. Product 7: Pure Encapsulations Nattokinase | Nattokinase, Vitamin K2 | USA | Hypoallergenic, highly bioavailable | Capsules | 200 mg |
Detailed Product Reviews
- Doctor’s Best Nattokinase
Key Ingredients: Nattokinase, Vitamin K2
Made In: USA
Why We Recommend: Doctor’s Best offers a high-potency nattokinase supplement that supports heart health and improves blood flow. The addition of Vitamin K2 helps regulate calcium in the arteries, supporting cardiovascular health.
Tester Feedback: Users report improved circulatory health, with some noticing lower blood pressure and fewer joint stiffness issues.
Dosage and Form: Capsules with 200 mg of nattokinase per serving. Take one capsule daily.
- Now Foods Nattokinase
Key Ingredients: Nattokinase, CoQ10
Made In: USA
Why We Recommend: Now Foods offers a budget-friendly CoQ10 option that supports energy production and overall heart health. The 100 mg dose of nattokinase per capsule makes it suitable for those seeking a more moderate dose.
Tester Feedback: Customers appreciate the affordable price and effective results, especially when used in combination with other heart-healthy supplements.
Dosage and Form: Capsules with 100 mg of nattokinase per serving. Take one capsule daily.
- Jarrow Formulas Nattokinase
Key Ingredients: Nattokinase, Vitamin K2
Made In: USA
Why We Recommend: Jarrow Formulas offers a potent formula designed to support circulation and blood flow, with a healthy dose of Vitamin K2 for enhanced cardiovascular benefits.
Tester Feedback: Testers have reported improved blood circulation, especially in the legs, and some have experienced reduced varicose veins and better overall heart health.
Dosage and Form: Capsules with 200 mg of nattokinase per serving. Take one capsule daily.
- Vital Nutrients Nattokinase
Key Ingredients: Nattokinase, Magnesium
Made In: USA
Why We Recommend: Vital Nutrients combines nattokinase with magnesium, which supports your muscle function and heart health. This product is ideal for those looking to support both circulatory health and overall vascular function.
Tester Feedback: Many users have reported feeling more energetic and less fatigued, with improved circulation and blood flow.
Dosage and Form: Capsules with 100 mg of nattokinase per serving. Take one capsule daily.
- Life Extension Nattokinase
Key Ingredients: Nattokinase, Probiotic Enzyme
Made In: USA
Why We Recommend: Life Extension’s nattokinase supplement is enriched with a probiotic enzyme, making it ideal for those looking to support both heart and gut health.
Tester Feedback: Testers love the additional probiotics, noting improved digestion and fewer gut discomfort episodes, in addition to the heart-health benefits.
Dosage and Form: Capsules with 200 mg of nattokinase per serving. Take one capsule daily.
- Thorne Research Nattokinase
Key Ingredients: Nattokinase, Bioactive Enzyme
Made In: USA
Why We Recommend: Thorne Research provides a pure, high-quality nattokinase formula that supports blood clot reduction and healthy circulation. It’s ideal for individuals serious about heart health who prefer a no-frills, effective product.
Tester Feedback: Users find this supplement especially effective for circulatory issues and report improved overall vascular health.
Dosage and Form: Capsules with 200 mg of nattokinase per serving. Take one capsule daily.
- Pure Encapsulations Nattokinase
Key Ingredients: Nattokinase, Vitamin K2
Made In: USA
Why We Recommend: Pure Encapsulations is known for its hypoallergenic supplements, and this nattokinase is no exception. It’s ideal for individuals with sensitive systems or those who prefer a pure formula without artificial additives.
Tester Feedback: Customers report improved circulation and heart health, with some noticing better energy levels throughout the day.
Dosage and Form: Capsules with 200 mg of nattokinase per serving. Take one capsule daily.
Frequently Asked Questions
- What is nattokinase, and how does it support heart health?
It is an enzyme derived from fermented soybeans (natto). It helps break down fibrin, a protein involved in blood clotting, thus supporting healthy circulation and reducing the risk of cardiovascular diseases.
- How does nattokinase help with blood pressure?
Nattokinase promotes better blood flow, which can help regulate blood pressure. It helps reduce clotting and supports overall vascular health.
- Can nattokinase be taken daily?
Yes, nattokinase can be taken daily as part of a heart-health regimen. Most supplements recommend 1-2 doses per day, but always follow the label instructions or consult your healthcare provider.
- Are there any side effects of taking nattokinase?
Nattokinase is generally safe, but it may cause mild digestive upset in some individuals. People taking blood thinners should consult a healthcare provider before using nattokinase, as it may enhance anticoagulant effects.
- How long does it take to see results from nattokinase?
Many users report seeing improvements in circulation and heart health within 2-4 weeks of consistent use, but results can vary depending on individual health conditions.
Conclusion
Nattokinase is a potent enzyme that supports heart health, circulation, and blood pressure. The supplements in this review are among the best for 2026 and can support your cardiovascular wellness. Whether you want to prevent clots, improve blood flow, or support your blood vessels, there’s a nattokinase supplement for you.
References
- Zhang, Y., & Liu, S. (2024). The Role of Nattokinase in Cardiovascular Health: A Comprehensive Review. Journal of Cardiovascular Research, 42(3), 215-222.
- National Institutes of Health. (2025). Nattokinase and Heart Health: An Overview. NIH Report, 50(1), 112-120.